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Interesting Case of the Month - (IGHP, ICOM) - February

Clinical History-

38-year-old male presented with complaints of nausea, abdominal pain, anorexia and weight loss. He had history of lesion on the toes which was operated 3 years back.

Radiology-

UGIE show a small discolored area in duodenal mucosa. Biopsy was taken

Microscopic Images-

Microscopy showed patchy areas of infiltration of lamina propria by pigmented cells? Histiocytes? Atypical cells

Special Stains Performed-

PAS

Immunohistochemistry -

Immunohistochemistry performed for CD68, S100, HMB45, MelanA and SOX10. The neoplastic cells are positive for S100, HMB45 and Melan A. The cells were negative on CD56 and SOX10.

CD68

HMB45

MelanA

S100

SOX10

Diagnosis-

Celiac Disease

Metastatic Malignant Melanoma

Whipple’s Disease

Metastatic Carcinoma

Case of the Month

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