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Interesting Case of the Month - (IGHP, ICOM) - November

november 2024

Clinical History-

54-year-old male with abdominal pain and obstructive jaundice. Underwent EUS guided biopsy from the head mass.

From the images below identify the likely disease.

On endoscopy-

EUS- showed mass in head of pancreas

Microscopic Images-

Histology images showed small bowel mucosa with presence of a neoplasm composed sheets of cells.

Immunohistochemistry Performed-

Immunohistochemistry performed showed the atypical cells are negative on Synaptophysin, Chromogranin, CK7, TTF1, CDX2 with Ki67 index of 40-50%. IHC was positive for CK20 and GATA 3

Diagnosis-

Neuroendocrine Tumor
Metastatic Urothelial Carcinoma
Insulinoma
Metastatic Breast Carcinoma