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Interesting Case of the Month - (IGHP, ICOM) - August

august

Clinical History-

16-year-old boy with multiple episodes of vomiting and low oral intake. USG abdomen showed a hypoechoic lesion in the liver measuring 6.7 x 6.1 cm in the portal confluence region. There was non-visualization of right and left hepatic ducts, their confluence and the proximal common hepatic duct. PET CT revealed FDG)-avid hypodense lesion was seen in the right lobe of the liver (segments 5-8). Ulceration with irregular thickening was observed in the cecum, distal ileum and ascending colon, with a maximum mural thickness of 1.5 cm. Liver and colon biopsy was performed for evaluation. From the images below identify the likely disease?

Radiology Images-

(A) An ultrasonography image shows a large hypoechoic lesion measuring 6.7×6.1 cm in the region of portal confluence involving segments 5, 6, and 7 of the liver. (B) Colour doppler reveals mild colour flow within the lesion. (C) Transverse relaxation time fat-saturation magnetic resonance imaging of the liver demonstrates heterogeneously hyperintense signal intensity lesion.

Microscopic Images-

Special Stains-

PAS stain and GMS stain

A. Cholangiocarcinoma Liver
B. Eosinophilic Gastroenteritis with liver abscess
C. Mesenchymal Hamartoma Liver
D. Fungal spores with Splendore-Hoeppli phenomenon