Interesting Case of the Month - (IGHP, ICOM) - June
june
Clinical History-
40-year-old male had history of metabolic syndrome with fatty liver,hypothyroidism, dyslipidemia & obesity. He had asymptomatically altered LFT for 4 years, followed by jaundice for 1 year with history of slow activity and forgetfulness forlast 6 months. Current LFT Total Bilirubin-4.5 mg/ dl, AST/ ALT-96/ 256 U/L, SAP/ GGT-190/ 250 U/L, Albumin-3.6 g/ dl. INR-1.2.
The jaundice was painless progressive with itching all over body for about 3months with passage of cholic stool. UGIE-Small esophageal varices.
Radiology-
CECT Abdomen Triple Phase-Features of Chronic Liver Disease and hypodense non enhancing focal lesions likely focal fatty change
PET Scan-Multifocal FDG PET-CT fused axial imageshows diffuse areas of FDG uptake in bothlobes of liver
Microscopic Images-
Special Stains-
Rhodanine showed copper deposits in peri septal hepatocytes and MT stain showing nodularity
Immunohistochemistry –
IHC for HepPar1, CD1a and S100
