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Interesting Case of the Month - (IGHP, ICOM) - June

june 2024

Clinical History-

34-year-old malepresented with history of chronic diahorrhea with infiltrative liver disease. UGIE-Reduced duodenal folds and antral region hyperemia

Microscopic Images-

Histology showing areas of villous blunting by moderate expansion of superficial lamina propria by dense aggregates of foamy histiocytes along with lympho-plasmacytic inflammation.

Special Stains-

PAS stain - Faint staining noted within the histiocytes.

ZN Stain multiple AFB noted within the histiocytes.

GMS Stain - The bacilli in histiocytes are weakly silver positive

Diagnosis-

Whipple’s Disease
Crystal storing histiocytosis
Mycobacterium Avium Intracellulare
Cryptosporidiosis