Interesting Case of the Month - (IGHP, ICOM) - May
may 2024
Clinical History-
25-year-old femalepresented with complaints of abdominal fullness, itching, static weight 33 kgs for 2-3 years, intermittent fever. She also had history of sickle cell anemia since the age of 2-3 years, underwent splenectomy for same. History of abdominal koch’s received ATT for 1 year.
USG Examination: Coarse hepatomegaly 23.2 cm. Enlarged necrotic pre and paraaortic lymph nodes.
LFT: Total Bill 0.63 / 0.12 mg/ dl SGOT 46IU/ l SGPT 25IU/ L SAP: 502IU/ L, Albumin -3.59, TLC 16600, INR-1.012
From the images below identify the likely disease?
Microscopic Images-
Histology showing large ovoid histiocytes within the sinusoids noted mainly in perivenular region. These cells have abundant fibrillary cytoplasm resembling wrinkled tissue paper appearance.
Special Stains-
MT stain showed presence of pericellular fibrosis. The vacuolated cells are PAS positive and Diastase resistant..
