Interesting Case of the Month - (IGHP, ICOM) - June
june 2026
Clinical History-
59-year-old malewithunderwent appendectomy for mucocele of appendix.
From the images below identify the likely disease?
Microscopic Images-
Microscopic examination from the appendix showed an attenuated wall lined by a layer of stratified mucinous epithelium, which is predominantly flattened in nature. The neoplastic cells exhibit nuclear stratification and low-grade cytologic features with abundant intracellular mucin. There are small deposits of large atypical cells on the serosal aspect.
Immunohistochemistry -
Immunohistochemistry for CK7, CK20, CDX2, PAX8, TTF1, GATA3, PSA were performed. The serosal deposits were positive for CK20 and negative for CK7. The appendix luminal wall is positive for CK20 and negative for CK7. The deposits was negative for all other markers.
Radiology-
FDG PET CT: Subsequent to histology patient underwent FDG PET CT which showed FDG avid enhancing wall thickening of entire gall bladder having ill-defined fat planes with adjacent liver parenchyma with significant surrounding FDG avid nodular stranding.
