Interesting Case of the Month - (IGHP, ICOM) - December
december 2025
Clinical History-
43-year-old malek/c/o CA pancreas biopsy proven. Underwent Whipple’s resection for ca pancreas. Intraoperative a nodule found on liver surface. Sent for frozen section and histology.
From the images below identify the likely disease?
Frozen Section-
Frozen section examined showed a lesion with proliferated ductules
Microscopic Images-
Microscopic examination showed an unencapsulated proliferation of uniformly spaced ductules lined by bland, cuboidal epithelium in a collagenous stroma. The architecture seems non-infiltrative, with evidence of entrapped native portal tracts present within the lesion itself.
Special Stains Performed-
MT Stain highlighted areas of fibrosis
Immunohistochemistry Performed-
Ki67 IHC showed similar expression as surrounding ductulesin portal tracts
Diagnosis-
Metastatic carcinoma
Secondary sclerosing cholangitis
Bile duct adenoma
Von Meyenberg Complex
